Certified Pediatric Hematology Oncology Nurse (CPHON) Practice Exam

In the context of hereditary spherocytosis management, splenectomy, which is the surgical removal of the spleen, plays a significant role in enhancing the lifespan of red blood cells. Individuals with hereditary spherocytosis have red blood cells that are abnormally shaped and are typically prone to hemolysis, particularly within the spleen.

The spleen acts as a filter for blood, identifying and removing damaged or irregular red blood cells. By removing the spleen through splenectomy, the process of destruction of these spherocytes is reduced, allowing for a greater proportion of red blood cells to survive longer in circulation. This results in fewer symptoms related to anemia and improved overall blood counts for affected individuals.

While splenectomy does not cure hereditary spherocytosis, it significantly improves the quality of life by mitigating the complications associated with hemolytic anemia, such as fatigue and jaundice. This understanding of splenectomy's impact aligns with the selected answer regarding its role in prolonging the lifespan of red blood cells.