Which nutrient deficiency can lead to maturation defects in bone marrow failure?

Maturation defects in bone marrow failure can be significantly influenced by Vitamin B12 deficiency. This vitamin is crucial for DNA synthesis and red blood cell formation, playing a vital role in the proper maturation of hematopoietic cells in the bone marrow. When there is insufficient Vitamin B12, it affects the production of healthy red blood cells, potentially leading to anemia and various maturation defects due to impaired cell division and differentiation.

In terms of their importance to bone marrow health and function, the other nutrients listed do not have the same critical impact on hematopoiesis as Vitamin B12. While Vitamin K is essential for blood clotting, Vitamin D plays a role in calcium metabolism and bone health, and Vitamin A is important for immune function and vision, none of these are directly linked to the specific issues of cell maturation within the bone marrow in the context of deficiency that arises from a lack of Vitamin B12.